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Updated: Nov 7, 2025

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
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Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

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免疫媒介疾患における免疫細胞特異遺伝子調節のダイナミックな風景

Mineto Ota1, Yasuo Nagafuchi1, Hiroaki Hatano2

  • 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

Cell
|April 30, 2021
PubMed
まとめ

この研究では,免疫媒介性疾患の患者からの免疫細胞の遺伝子発現をマッピングしています. 遺伝子の変異が 細胞の種類や疾患状態によって 遺伝子の活動に 異なった影響を及ぼすことを明らかにし 病気のメカニズムへの洞察を提供します

キーワード:
東京大学からの免疫細胞遺伝子表現アトラス細胞型に固有のeQTL文脈に依存するeQTL表現 定量的な特性の位置遺伝子調節免疫細胞免疫媒介性疾患免疫遺伝学全身性赤血性狼トランスクリプトーム

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