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Updated: Nov 6, 2025

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SETDB1によるエピジェネティック・サイレンシングは,腫瘍内在の免疫性を抑制する

Gabriel K Griffin1,2,3, Jingyi Wu1,2, Arvin Iracheta-Vellve1

  • 1Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Nature
|May 6, 2021
PubMed
まとめ

この研究では,SETDB1が抗腫瘍免疫を抑制する重要な表遺伝子調節因子として特定されています. SETDB1の喪失は,免疫反応を活性化することによって,免疫療法に対するがん細胞の感受性を高めます.

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