幼児期からの心血管リスク要因の軌跡と中年の認知能力:若いフィンランド人の心血管リスクの研究
Juuso O Hakala1,2,3, Katja Pahkala1,2,3, Markus Juonala4,5
1Research Centre of Applied and Preventive Cardiovascular Medicine (J.O.H., K.P., P.S., O.T.R., S.P.R.), University of Turku, Finland.
Circulation
|May 10, 2021
まとめ
高血圧やコレステロールなどの 心血管疾患の危険因子は 幼児期から中年期まで 認知機能に悪影響を及ぼします リスク要因が蓄積されるほど 認知能力が低下します
科学分野:
- 神経科学
- 心臓病科
- 公衆衛生
背景:
- 中年の心血管疾患の危険因子は 認知能力の低下と関連しています
- 幼児期から蓄積された心血管の危険因子の認知能力への影響に関する長期的データは限られている.
研究 の 目的:
- 幼児期から中年期までの心血管疾患の危険因子,その蓄積,成人期における認知能力との関連を調査する.
主な方法:
- 3596人の子ども (3~18歳) の集団を31年間追跡した.
- 心血管の危険因子 (血圧,脂質,BMI) を繰り返し評価した.
- 潜在的クラス成長混合モデリングにより,リスク因子の軌跡が特定され,認知テストは2026人の参加者 (34歳から49歳) で実施された.
主要な成果:
- 一貫して高血圧と総コレステロールは,エピソード記憶と関連学習の低下と関連付けられました.
- 子供の頃の肥満は 視覚的処理と注意力の低下と相関しています
- 心血管リスク因子の蓄積は,エピソード記憶,関連学習,視覚処理,持続的注意力,および反応時間との逆関連を示した.
結論:
- 血圧の上昇,血清の総コレステロール,そして幼児期から中年期までの肥満は 中年期の認知能力と正反対に関連しています
- 心血管リスク因子の増加は 認知機能の低下と相関しています
- 心血管の危険因子を標的とした幼少期の介入戦略は 成人の認知健康を促進する可能性があります.
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