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Updated: Nov 5, 2025

High Sensitivity 5-hydroxymethylcytosine Detection in Balb/C Brain Tissue
07:19

High Sensitivity 5-hydroxymethylcytosine Detection in Balb/C Brain Tissue

Published on: February 1, 2011

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システインクランプドメインの選択的非メチル化CpGDNA認識メカニズム

Bo Duan1, Dihong Fu1, Chaoqun Zhang1

  • 1Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, and School of Life Sciences, Peking University, Beijing 100871, China.

Journal of the American Chemical Society
|May 13, 2021
PubMed
まとめ

転写因子TCFとGEFタンパク質は,C-クランプの亜鉛指を使用して非メチル化DNAを結合する. CpGのメチル化は結合を阻害し,重要な表遺伝的調節メカニズムを明らかにする.

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