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ストレス誘発の分裂からSLFN2のtRNAの保護は,T細胞媒介免疫にとって不可欠である

Tao Yue1, Xiaoming Zhan1, Duanwu Zhang1

  • 1Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Science (New York, N.Y.)
|May 14, 2021
PubMed
まとめ

T細胞の活性化中に活性酸素種 (ROS) が増加し,トランスレーション抑制を引き起こします. スクラフェン2 (SLFN2) タンパク質は,トランスファーRNA (tRNA) を分裂から保護し,T細胞の増殖と免疫を可能にします.

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