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Updated: Nov 5, 2025

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

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ゲートキーピングケトシンタゼ ディクテート 組み立てラインの開始 ピロリックポリケチドの生物合成

Dongqi Yi1, Atanu Acharya2, James C Gumbart1,2

  • 1School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.

Journal of the American Chemical Society
|May 14, 2021
PubMed
まとめ

ケトシンタゼ (KS) ドメインは,ポリケチド生物合成における重要なチェックポイントとして機能し,正しい中間検証を保証する. これらの KS ドメインのエンジニアリングは,新しい天然製品発見のためにポリケチドアセンブリラインの再プログラミングを可能にします.

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Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis...
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