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Updated: Nov 5, 2025

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers
10:49

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers

Published on: September 26, 2019

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PP2A-Integrator-CDK9軸はトランスクリプションを微調整し,がんの治療をターゲットにすることができます

Stephin J Vervoort1, Sarah A Welsh2, Jennifer R Devlin1

  • 1Peter MacCallum Cancer Centre, Melbourne 3000, VIC, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville 3010, VIC, Australia.

Cell
|May 18, 2021
PubMed
まとめ

新しく発見されたタンパク質フォスファタゼ2A (PP2A) 複合体は,遺伝子調節におけるサイクリン依存キナーゼ9 (CDK9) 活性に対抗する. この発見は,PP2Aの活性化とCDK9の抑制を組み合わせた新しい治療戦略を示しています.

キーワード:
CDK9 についてCRISPR-Cas9スクリーンCTDインテグラータPP2A についてPP2Aの活性化RNAポリメラーゼII癌についてパズルリリースリン酸塩トランスクリプションの延長

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Published on: May 14, 2016

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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors10:33

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