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Updated: Nov 5, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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DNAポリメラーゼβの選択的阻害

Shelby C Yuhas1, Daniel J Laverty1, Huijin Lee1

  • 1Johns Hopkins University, Department of Chemistry, 3400 North Charles Street, Baltimore, Maryland 21218, United States.

Journal of the American Chemical Society
|May 20, 2021
PubMed
まとめ

研究者はDNA修復と癌における重要な酵素であるDNAポリメラーゼβ (Pol β) を選択的に標的とする新しい共性阻害剤を開発した. このPol β阻害剤は,疾患とがん治療におけるその役割の研究のツールとして有望である.

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