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Updated: Nov 4, 2025

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
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SARS-CoV-2 ゲノムにおける非コーディング要素のコンフォメーションアンサンブルは,分子動態シミュレーションから得られた

Sandro Bottaro1, Giovanni Bussi2, Kresten Lindorff-Larsen1

  • 1Structural Biology and NMR Laboratory & Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, DK-2200 Copenhagen N, Denmark.

Journal of the American Chemical Society
|May 27, 2021
PubMed
まとめ

研究者は,SARS-CoV-2 5' 未翻訳領域の5つのRNA幹ループの3D構造をシミュレートした. これらのシミュレーションは,ウイルスに対する潜在的な薬剤設計に重要なダイナミックな再編成を明らかにします.

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