インヴァリアントなトライパノソーマ・ビバックスワクチンの抗原は,保護的な免疫を誘発する

Delphine Autheman¹, Cécile Crosnier¹, Simon Clare²

¹Cell Surface Signalling Laboratory, Wellcome Sanger Institute, Hinxton, UK.

Nature

|May 27, 2021

まとめ

研究者たちは,この寄生虫に対して長期に続く保護を引き起こす肝要なタンパク質を特定しました. この発見は,アフリカのトライパノソミアシスおよび関連する家畜の病気に対する有望なワクチン候補を提供します.

科学分野:

寄生虫学
免疫学
ワクチン学

背景:

トリパノソームは人間と家畜の重要な病気を引き起こす.
トリパノソームの抗原変異はワクチン開発を妨げます
アフリカトライパノソミアシスはサハラ以南のアフリカの社会経済発展に影響を及ぼします

研究の目的:

トリパノソーマ寄生虫に対する不変のワクチン抗原を特定する.
アフリカトライパノソミアシスとナナガのワクチンを開発する

主な方法:

ゲノム主導のワクチンアプローチ
トリパノソーマ・ビバックス感染のマウスモデル
リコンビネントインヴァリアントフラゲル抗原によるワクチン接種

主要な成果:

単一の再結合タンパク質 (不変性フラゲル抗原) が長期にわたる保護を誘導した.
免疫は血清とモノクローナル抗体で伝達された.
抗体媒介免疫は,補完体の活性化を含んでいる.

結論:

トリパノソーム感染に対する有望なワクチン候補を特定した.
高度な保護性を持つトリパノソームワクチンの実現可能性を示した.
免疫における抗体と補完体の役割が強調されています.

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