(+) - A

Moritz J Classen1, Markus N A Böcker1, Remo Roth1

  • 1ETH Zürich, Department of Chemistry and Applied Biosciences, Laboratory of Organic Chemistry, Vladimir Prelog Weg 3, 8093 Zürich, Switzerland.

まとめ

研究者らは,複雑な天然産物である (+) - ユーフォリカニンAを初めて完全合成した. SmI2を媒介する重要な反応により 独特の四環原子核が効率的に構築され 合成技術のさらなる進歩が可能になった.

関連する概念動画

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Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction

α-Substituted ketones or aldehydes can be synthesized from enamines by the Stork enamine reaction, named after its pioneer Gilbert Stork. Enamines are useful synthetic intermediates where the lone pair on nitrogen is in conjugation with the C=C bond. They resemble enolate ions, as the resonance forms of both species have a nucleophilic α carbon.
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Sharpless Epoxidation

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In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.
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Regioselective Formation of Enolates01:33

Regioselective Formation of Enolates

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