SARS-CoV-2のRNA依存RNAポリメラーゼにおけるFe-S共因子は,潜在的な抗ウイルス標的である

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Updated: Nov 3, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
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Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

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Nunziata Maio1, Bernard A P Lafont2, Debangsu Sil3

  • 1Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|June 4, 2021
PubMed
まとめ

研究者らは,ウイルスの複製に不可欠なSARS-CoV-2のRNA依存RNAポリメラーゼ (RdRp) で鉄硫黄のクラスターを発見した. これらのクラスタをTEMPOLで抑制することで,COVID-19ウイルスの複製を阻止し,新たな治療標的を明らかにした.

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