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Updated: Nov 3, 2025

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
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Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

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トリメリック・ヒドロフォビック・ジッパーは,SARS-CoV-2スパイクの膜内アセンブリを媒介する

Qingshan Fu1, James J Chou1

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States.

Journal of the American Chemical Society
|June 4, 2021
PubMed
まとめ

SARS-CoV-2 Sタンパク質トランスメブラン領域 (TMD) は安定したトリマーを形成し,NMRによって明らかにされる. この構造はレウシンジッパーに似ており,ウイルスの侵入メカニズムと潜在的な治療標的の洞察を提供します.

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