関連する実験動画

Updated: Nov 2, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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TF-PROTACは,トランスクリプション・ファクターの標的化された劣化を可能にします

Jing Liu1, He Chen2, H Ümit Kaniskan2

  • 1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, United States.

Journal of the American Chemical Society
|June 8, 2021
PubMed
まとめ

トランスクリプション・ファクター (TF) は薬効性のない標的ですが,TF-PROTACは新しい戦略を提供します. これらの分子はDNAを使って 選択的にTFを分解し 癌治療の有望性を示しています

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