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Updated: Nov 2, 2025

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer
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TIM-3は,炎症体活性化を調節することによって,抗腫瘍免疫を抑制する

Karen O Dixon1,2,3, Marcin Tabaka3, Markus A Schramm1,2,4

  • 1Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.

Nature
|June 10, 2021
PubMed
まとめ

T細胞ではなく,デンドリット細胞のT細胞免疫 globulinとムシン含有分子3 (TIM- 3) をブロックすると,抗腫瘍免疫が強化されます. dendritic 細胞の TIM - 3 の喪失は,この免疫反応に不可欠な NLRP3 炎症体を活性化します.

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