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Cell Migration

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.

Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

Overview of Cell-Matrix Interactions

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

Cell-matrix's Response to Mechanical Forces

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...

Cadherins in Tissue Organization

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
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Adherens Junctions

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic

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Updated: Nov 2, 2025

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

細胞-マトリックス対細胞-細胞付着による芽生えた上皮の形態変異

Shaohe Wang¹, Kazue Matsumoto¹, Samantha R Lish²

¹Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

|June 16, 2021

まとめ

この要約は機械生成です。

臓器の発達に不可欠な層状の上皮の芽生えは特定の細胞の結合特性によって引き起こされます強い細胞マトリックスと弱い細胞-細胞結合は,この重要なステップを可能にします.

キーワード:

エカデリン枝分かれする形態形成芽生える形質形成細胞同士の結合細胞マトリックス粘着微分粘着エピテリアモルフォゲネシスインテグリン唾液腺組織工学

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Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

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関連する実験動画

Last Updated: Nov 2, 2025

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading

Published on: May 22, 2021

科学分野:

発達生物学
細胞生物学
バイオ物理学

背景:

唾液腺や臓のような複雑な臓器の形成には皮質の形態変異が不可欠です
層状の表皮細胞の芽生えと枝分かれを駆動するメカニズムは完全に理解されていません.

研究の目的:

胚の臓器発達の過程で層状の上皮細胞の芽生えを促す細胞および分子的要因を解明する.
枝分かれする形質形成の開始における細胞粘着の役割を調査する.

主な方法:

単細胞解像度でのマウス胚唾液腺の生体器官イメージング
空間的な遺伝子発現パターンを特定するための単細胞トランスクリプトームのプロファイリング
3D球形培養は,細胞粘着分子 (E-カデリン) の実験的操作と基礎膜誘導によるものです.

主要な成果:

芽生える形態化は,強い細胞マトリックスと弱い細胞結合を持つ上皮細胞によって引き起こされる.
空間的な転写パターンは,観察された細胞結合の違いと相関する.
合成解により,抑制されたE-カデリンと,β1-インテグリンシグナル伝達による誘導された基礎膜が芽生えることを確認した.

結論:

層状の上皮芽は,異なる粘着特性を持つ明確な細胞シートによって開始されます.
強い細胞-マトリックス粘着と弱い細胞-細胞粘着は,枝分かれの形態変異の初期芽生え段階において重要である.
この研究は,臓器形成に不可欠な上皮の芽生えの仕組みを理解します.