鼻から脳幹までのペプチダーギー経路によって発散する
Fengxian Li1, Haowu Jiang1, Xiaolei Shen1
1Department of Anesthesiology, Center for the Study of Itch and Sensory Disorders, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cell
|June 16, 2021
まとめ
科学者たちは 新しい神経経路を発見しました ニューロメディンB (NMB) ペプチドは,脳幹のNMB感受性ニューロンを介して,この重要な呼吸反射を誘発します.
科学分野:
- 神経科学
- 呼吸器の生理学
- 分子生物学
背景:
- 吐き気はアレルギーや感染症などの 呼吸器系の問題とよく結びついている 重要な反射です
- 精密な神経回路が 排気を制御する方法は ほとんど解明されていません
- 以前の研究では 脳幹に 打たれを誘発する領域が 発見されました
研究 の 目的:
- 神経回路と分子メカニズムを 解明する
- 鼻からの感覚情報を脳幹に伝達する特定の神経伝達物質を特定する.
- ニューロメディンB (NMB) がニキビを媒介する役割を調査する.
主な方法:
- 鼻の感覚神経細胞によって放出される神経伝達物質/神経ペプチドのスクリーニング
- 動物モデルでのNMB感受性ニューロンの除去とNMB受容体の欠乏に関する研究.
- 鼻をひそめる領域からの神経突起の解剖学的な追跡.
- 特定のニューロン集団の 電気生理学的記録と化学的活性化
主要な成果:
- ニューロメディンB (NMB) は,スニッコのシグナル伝達に不可欠なキーペプチドとして特定されました.
- NMB感受性ニューロンを切断したり NMB受容体を遮断したりすると 打つ反射が解消されます
- NMBに敏感なニューロンは尾関節内側呼吸器群 (cVRG) に発射される.
- これらのニューロンの活性化により,cVRGニューロンのアクションポテンシャルが誘発され,スニッコが誘発された.
結論:
- NMBを含む新しいペプチダージック経路が 打つ反射を媒介する.
- この経路は,脳幹のNMB感受性ニューロンが cVRGに投影する.
- この発見は の反射弧の神経生物学について 重要な分子洞察をもたらします
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