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Updated: Nov 1, 2025

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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CTLA-4依存フィードバックループの破壊により,腫瘍に関連したTreg細胞の拡張

Francesco Marangoni1, Ademi Zhakyp2, Michela Corsini3

  • 1The Center for Immunology and Inflammatory Diseases (CIID), Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA; Institute for Immunology, University of California, Irvine, Irvine, CA 92697, USA.

Cell
|June 22, 2021
PubMed
まとめ

Foxp3+ T調節細胞 (Treg) は, dendritic cells (cDCs) と相互作用することによって,腫瘍の耐性を制御する. トレグ細胞はCTLA-4を使って 自身の活性化を制限し 腫瘍の拒絶に不可欠なプロセスです

キーワード:
CD28 についてCTLA-4 についてMP-IVM についてNFAT についてT調節セルトレグ細胞細胞毒性Tリンパ球関連タンパク質4マルチフォトン内視顕微鏡活性化されたT細胞の核因数腫瘍耐性

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