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関連する概念動画

ATP Driven Pumps I: An Overview01:27

ATP Driven Pumps I: An Overview

9.1K
ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
9.1K
ATP Driven Pumps II: P-type Pumps01:34

ATP Driven Pumps II: P-type Pumps

5.5K
The P-type pumps are a large family of integral membrane transporter ATPases. They are divided into five major types based on substrate specificity, from I to V.
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
5.5K
ATP Driven Pumps III: V-type Pumps01:30

ATP Driven Pumps III: V-type Pumps

4.2K
V-type pumps are ATP-driven pumps found in the vacuolar membranes of plants, yeast, endosomal and lysosomal membranes of animal cells, plasma membranes of a few specialized eukaryotic cells, and some prokaryotes. They are also known as the V1Vo-ATPase, that couple ATP hydrolysis to transport protons against a concentration gradient.
The peripheral or cytosolic V1 domain with eight subunits is involved in ATP hydrolysis. The integral or transmembrane V0 domain containing at least five subunits...
4.2K
Introduction to Mechanisms of Enzyme Catalysis01:13

Introduction to Mechanisms of Enzyme Catalysis

9.4K
For many years, scientists thought that enzyme-substrate binding took place in a simple "lock-and-key" fashion. This model stated that the enzyme and substrate fit together perfectly in one instantaneous step. However, current research supports a more refined view scientists call induced fit. The induced-fit model expands upon the lock-and-key model by describing a more dynamic interaction between enzyme and substrate. As the enzyme and substrate come together, their interaction causes...
9.4K
ATP Synthase: Mechanism01:48

ATP Synthase: Mechanism

15.7K
In animals, the mitochondrial F1F0 ATP synthase is the key protein that synthesizes ATP molecules through a complex catalytic mechanism. While the nuclear genome encodes the majority of ATP synthase subunits, the mitochondrial genome encodes some of the enzyme's most critical components. The formation of this multi-subunit enzyme is a complex multi-step process regulated at the level of transcription, translation, and assembly. Defects in one or more of these steps can result in decreased...
15.7K
Chemiosmosis01:32

Chemiosmosis

106.7K
Oxidative phosphorylation is a highly efficient process that generates large amounts of adenosine triphosphate (ATP), the basic unit of energy that drives many cellular processes. Oxidative phosphorylation involves two processes— the electron transport chain and chemiosmosis.
Electron Transport Chain
The electron transport chain involves a series of protein complexes on the inner mitochondrial membrane that undergo a series of redox reactions. At the end of this chain, the electrons...
106.7K

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Updated: Nov 1, 2025

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
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Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

11.6K

触媒を駆動する人工分子ポンプ

Shuntaro Amano1, Stephen D P Fielden1, David A Leigh2,3

  • 1Department of Chemistry, University of Manchester, Manchester, UK.

Nature
|June 24, 2021
PubMed
まとめ
この要約は機械生成です。

この研究では 化学的に燃料を供給された自律的な分子ポンプを導入し マクロサイクルを軸に継続的に移動させます この新しい情報ラッチは 外部の介入なしに動作し 分子機械の研究を進めています

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Preparation and 3D Tracking of Catalytic Swimming Devices
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関連する実験動画

Last Updated: Nov 1, 2025

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
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Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

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Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
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Preparation and 3D Tracking of Catalytic Swimming Devices
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科学分野:

  • 分子機械
  • 超分子化学
  • カタリシス

背景:

  • 生物学的なポンプは,触媒化学燃料分解を用いて細胞の均衡状態を維持します.
  • 既存の人工分子ポンプは限られており,反応剤の添加や電気ポテンシャルの変化などの軽量または繰り返しの外部介入が必要です.

研究 の 目的:

  • 分子ポンプ用の 化学的に燃料を供給する 自動制御された情報ラッチを 記述する
  • 外部の介入なしにマクロサイクルを分子軸に継続的にポンプする.

主な方法:

  • 軸上のマクロサイクルの位置がバリアの固定と除去に影響を与える情報ラッチメカニズムを使用します.
  • 低エネルギー状態から高エネルギー状態への継続的なポンプを可能にするために,バリアプロセスのダイナミクスを調整します.
  • 複数のマクロサイクルを軸にポンプすることで,ラッチの動作を実験的に実証する.

主要な成果:

  • 化学的に燃料を供給する 分子ポンプを開発しました
  • 連続して3つのクローンエーテルマクロサイクルを分子軸にポンプする.
  • 化学燃料が存在する限り,持続的なバランスの外 [n]ロタキサンが得られる.

結論:

  • 触媒は人工分子ポンプを駆動し 研究の新たな道を開くことができます
  • 開発された情報ラッチは 自律的な分子機械のための新しいパラダイムを提供します.
  • この研究は触媒と分子機構の橋渡しとなり 新しい洞察と応用が可能になります