カロリー制限は微生物群と植民抵抗性を破壊する
Reiner Jumpertz von Schwartzenberg1,2,3, Jordan E Bisanz4, Svetlana Lyalina5
1Charité Universitätsmedizin Berlin, Department of Endocrinology and Metabolic Diseases, Berlin, Germany.
Nature
|June 24, 2021
まとめ
重度のカロリー制限は腸内微生物を変化させ ホストの代謝と栄養吸収に影響します ダイエットによる微生物群の変化は,体重減少と宿主の生理学的変化につながります.
科学分野:
- 微生物学
- 人間の生理学
- 代謝 健康
背景:
- ダイエットは腸内微生物の組成に大きな影響を与えます
- 食事による微生物群の変化が宿主の健康に与える影響は完全に理解されていません.
研究 の 目的:
- 低カロリー食がヒトの腸内微生物群に与える影響を 研究するためです
- マウスモデルを用いて宿主の病理生理学に対する食事による微生物群の変化の影響を決定する.
主な方法:
- ランダム化されたヒト介入研究で 非常に低カロリーな食事
- ヒトからの微生物群の移植 (食事前のおよび食事後の) を細菌のないマウスに.
- ホストの体重,脂肪,栄養吸収,微生物の組成の評価
主要な成果:
- 厳しいカロリー摂取制限により 細菌の数が減り 腸内微生物群が再構築されました
- ダイエット後の微生物群をマウスに移植すると,体重が減り,脂肪が増加しました.
- ネズミの体重減少は,栄養素吸収の低下,Clostridioides difficileの濃縮,および胆酸の減少と関連していました.
結論:
- 食事と微生物の相互作用は宿主のエネルギーバランスを調節するのに不可欠です.
- 病原菌と有益な微生物の相互作用における食事の役割を理解することは 代謝の健康に不可欠です
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