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Updated: Nov 1, 2025

CRISPR-Mediated Reorganization of Chromatin Loop Structure
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CRISPR-Mediated Reorganization of Chromatin Loop Structure

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フェーズ分離は異常なクロマチンのループと癌の発生を促す

Jeong Hyun Ahn1,2, Eric S Davis3, Timothy A Daugird4

  • 1Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

Nature
|June 24, 2021
PubMed
まとめ

癌タンパク質の内在的に乱れた領域 (IDR) は,相隔離コンデンサートを形成することによって腫瘍生成を誘導する. これらの凝縮物は遺伝子ターゲティングを強化し,3Dクロマチンの構造を変更し,白血病の発症を促進します.

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Epigenetic Regulation

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X-chromosome...
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