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The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

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Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
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Rab Cascades01:25

Rab Cascades

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Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
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Structure of Cadherins01:25

Structure of Cadherins

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The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
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Catenins01:23

Catenins

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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
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Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
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Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

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The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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Cell sorting plays an...
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Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
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Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
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発現した再結合カデリンは,モデルシステムにおける細胞分類を媒介する.

A Nose1, A Nagafuchi, M Takeichi

  • 1Department of Biophysics, Faculty of Science, Kyoto University, Japan.

Cell
|September 23, 1988
PubMed
まとめ

カデリンは細胞粘着を媒介する. 特定のカデリン,例えばE-カデリンやP-カデリンをL細胞で発現させることで,細胞の分類と組織組織化が方向づけられ,カデリンが示される.

科学分野:

  • 細胞生物学 細胞生物学
  • 発達生物学 発達生物学とは
  • 分子生物学は分子生物学である.

背景:

  • カデリンは,カルシウムに依存する細胞間粘着を媒介する重要な細胞表面グリコプロテインです.
  • カデリンの差異的発現は,組織形態変異と細胞分類に役割を果たすという仮説があります.
  • 内在的なカデリン活性がないL細胞は,カデリン機能を研究するためのモデルシステムとして機能します.

研究 の 目的:

  • 特定のカデリン亜種であるE-カデリンとP-カデリンが,細胞結合と分類を媒介する役割を調査する.
  • カデリン発現が異質な集団内の細胞の結合に影響を与えるかどうかを判断する.
  • 発達の文脈におけるカデリン媒介細胞分類の直接的な証拠を提供すること.

主な方法:

  • L細胞をE-カデリンまたはP-カデリン発現ベクトルで感染させる.
  • トランスフェクトされたL細胞の細胞集積と同型結合の評価.
  • トランスフェクトされたL細胞と胚性肺組織のエキスプラントを用いた再構成測定法.

主要な成果:

  • E-カデリンまたはP-カデリンでトランスフェクトされたL細胞は,Ca2+依存の細胞集積を示した.
  • トランスフェクトされた細胞は,同じカデリン亜種を発現する他の細胞に好ましい粘着性を示した.

さらに関連する動画

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In Vitro Reconstitution of Spatial Cell Contact Patterns with Isolated Caenorhabditis elegans Embryo Blastomeres and Adhesive Polystyrene Beads
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Last Updated: Apr 13, 2026

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Clonal Analysis of Embryonic Hematopoietic Stem Cell Precursors Using Single Cell Index Sorting Combined with Endothelial Cell Niche Co-culture
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  • 再構成された胚性肺組織では,E-カデリンを発現するL細胞は上皮組織構造に局所化し,トランスフェクトされていないL細胞はメゼンキマ成分に関連しています.

    • 結論:

    • 発現するカデリンの種類が,細胞粘着特異性を決定する.
    • 微分カデリン発現は,複雑な細胞環境における細胞分類を推進する重要なメカニズムである.
    • これらの発見は,組織組織と発達におけるカデリンの役割の直接的な証拠を提供します.