関連する実験動画

Updated: Nov 1, 2025

Using the E1A Minigene Tool to Study mRNA Splicing Changes
10:25

Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

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RNAスプライシングの薬理学的な調節は,抗腫瘍免疫を強化する

Sydney X Lu1, Emma De Neef2, James D Thomas3

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.

Cell
|June 25, 2021
PubMed
まとめ

薬理学的スプライシング調節により,がん新抗原が生成され,抗腫瘍免疫とチェックポイント免疫療法が強化されます. このアプローチは T細胞の反応を誘発することで 癌の治療を改善するための 新しい戦略を提供します

キーワード:
PD1 についてPRMTs についてRBM39 についてRNA スプライシング免疫チェックポイントの封鎖免疫ペプチドーム免疫療法ネオアンチゲンネオピトープスプライシング

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