Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Inflammatory Response01:28

Inflammatory Response

13.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
13.8K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

13.5K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
13.5K
Inflammation01:38

Inflammation

56.9K
Overview
56.9K
Adherens Junctions01:24

Adherens Junctions

5.4K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
5.4K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

6.3K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
6.3K
Surface Membrane Barriers01:18

Surface Membrane Barriers

1.8K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.8K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Aneuploidy selects for the acquisition of driver genes in breast cancer.

Nature·2026
Same author

Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.

Immunity·2026
Same author

<i>SPP1</i><sup>hi</sup> macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium.

Science translational medicine·2026
Same author

ArchVelo: archetypal velocity modeling for single-cell multi-omic trajectories.

Nature communications·2026
Same author

Upadacitinib Achieved Rapid Response in Biologic-Refractory Immune Checkpoint Inhibitor-Related Enterocolitis.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Metadomain and metaloop genome interactions in mammalian T cells.

Cell reports·2026

関連する実験動画

Updated: Nov 1, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.5K

障壁組織における炎症的適応

Rachel E Niec1, Alexander Y Rudensky2, Elaine Fuchs3

  • 1Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA; Department of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.

Cell
|June 25, 2021
PubMed
まとめ

炎症を記憶し 将来の反応を改善します しかし この免疫記憶は 慢性的な炎症を助長することで 病気を悪化させる可能性があります

さらに関連する動画

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.2K
Investigating Intestinal Barrier Breakdown in Living Organoids
07:18

Investigating Intestinal Barrier Breakdown in Living Organoids

Published on: March 26, 2020

13.6K

関連する実験動画

Last Updated: Nov 1, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.5K
Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.2K
Investigating Intestinal Barrier Breakdown in Living Organoids
07:18

Investigating Intestinal Barrier Breakdown in Living Organoids

Published on: March 26, 2020

13.6K

科学分野:

  • 免疫学
  • 組織修復
  • 携帯電話通信

背景:

  • 表面上の表皮は 外部からの脅威に対する重要な障壁です
  • 表皮細胞と免疫細胞は 感染症の管理と 障壁の破損後の損傷の修復に協力します
  • 炎症的イベントは,後の免疫反応に影響を与える,持続的な組織変化につながる可能性があります.

研究 の 目的:

  • バリア組織における細胞通信ネットワークを 検討する.
  • 組織細胞と免疫細胞の統合を研究する.
  • 環境ストレスや炎症に 組織が適応する仕組みを理解する

主な方法:

  • バリア組織における細胞伝達に関する文献レビュー.
  • 免疫細胞の相互作用と組織幹細胞の役割の分析
  • 炎症記憶と組織適応への影響の検討

主要な成果:

  • 炎症的な経験は 組織の記憶を作り出し 将来の防御反応を高めます
  • 機能不全の炎症記憶は 病状を悪化させる可能性があります
  • エピテリア,免疫,幹細胞を含む複雑な細胞ネットワークが 組織の適応を促します

結論:

  • 組織記憶は 両刃の剣で 防御には不可欠ですが 病気には有害です
  • これらの細胞ネットワークを理解することは 炎症性疾患の管理の鍵です
  • これらのコミュニケーション経路をターゲットにすることで 組織修復と疾患制御の 治療戦略を提供できます