関連する実験動画

Updated: Oct 31, 2025

BioMEMS and Cellular Biology: Perspectives and Applications

BioMEMS and Cellular Biology: Perspectives and Applications

Published on: October 1, 2007

細胞流体学

Nikola A Dudukovic¹, Erika J Fong¹, Hawi B Gemeda¹

¹Lawrence Livermore National Laboratory, Livermore, CA, USA.

|July 1, 2021

まとめ

細胞流動学は3Dプリントされたユニット細胞ベースの構造を用いて,多相流動,輸送,反応を正確に制御します. この革新的なプラットフォームはガス-液体輸送や選択的な物質堆積などのアプリケーションでプログラムされた流体行動を可能にします

科学分野:

多相流と反応工学
バイオインスピレーションとバイオミメティック・システム
先進的な材料と製造方法

背景:

自然界のシステムでは多段階の輸送が最適化されています
既存の微流体装置は,複雑な多相工程に限られている.
流体制御のための生物学的システムの複製は大きな課題です

研究の目的:

決定的多相流動制御のための新しいプラットフォームとしてセルラー流動を導入します.
建築された細胞設計を通じて流体輸送のプログラム性を実証する.
ガス-液体輸送,蒸発冷却,CO2キャプチャの応用を探求する.

主な方法:

流体制御のための3Dプリント,ユニットセルベースの構造の開発.
細胞の種類,サイズ,密度を設計して流れの振る舞いをプログラムします
ガス-液体輸送,毛細血管駆動の流れ,そして活発なポンプの実験的な実証.
細胞流体装置内のパターン生成のための選択的金属化.

主要な成果:

発汗と吸収を含む,プログラム可能なガス-液体輸送が実証されています.
3Dセルラー流体装置で流体とガスの特有経路を展示しました
選択的な金属化がプログラムされたパターンで達成された
設計と予測モデリングを通じて流体輸送の決定的制御を検証した.

結論:

セルラー流動学は,3Dの多相輸送と反応を精密でプログラム可能な制御を提供します
設計された細胞材料と予測モデリングは決定的な流動制御の鍵です
このプラットフォームは多段階のプロセスにおける空間と時間の制御に革命をもたらす可能性を秘めています

さらに関連する動画

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

A Gradient-generating Microfluidic Device for Cell Biology

A Gradient-generating Microfluidic Device for Cell Biology

Published on: August 30, 2007

関連する概念動画

Fluid Movement Between Compartments

Fluid Movement Between Compartments

The force applied by fluids against a surface, known as hydrostatic pressure, initiates the transfer of fluid among different compartments. Within our blood vessels, the blood's hydrostatic pressure is a result of the heart's pumping action. At the arteriolar end of capillaries, hydrostatic pressure (capillary blood pressure) exceeds the opposing colloid osmotic pressure created primarily by plasma proteins like albumin. This discrepancy in pressure propels plasma and nutrients from the...

Capillarity in Fluid

Capillarity in Fluid

Capillarity describes the movement of liquid in small spaces without external forces acting on it. The capillarity is driven by surface tension and adhesive interactions between the liquid and surrounding solid surfaces. This effect is often seen in narrow tubes, porous materials, and fine particles.
Surface tension is crucial to capillarity. It results from cohesive forces between liquid molecules at the liquid-air boundary, forming a skin that resists external forces. When the capillary tube...

Types of Fluids

Types of Fluids

Fluids can be classified into Newtonian and non-Newtonian fluids based on their response to shear stress. Newtonian fluids have a linear relationship between shear stress and the shear strain rate, following Newton's law of viscosity. Their viscosity remains constant regardless of the shear rate, making their behavior predictable and easier to analyze. Common examples include water, air, oil, and gasoline.
In contrast, non-Newtonian fluids do not follow Newton's law of viscosity, and...

The Fluid Mosaic Model

The Fluid Mosaic Model

The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.

Transcellular Transport of Solutes

Transcellular Transport of Solutes

Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...

Characteristics of Fluids

Characteristics of Fluids

Fluids differ from solids primarily in their molecular structure and stress response. Solids have tightly packed molecules with strong intermolecular forces, maintaining their shape and resisting deformation. In contrast, fluids have molecules spaced farther apart with weaker forces, allowing them to flow and deform easily.
Fluids, which include both liquids and gases, are substances that deform continuously under shearing stress. For example, water and oil are liquids with molecules that can...