関連する実験動画

Updated: Oct 31, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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メタボトロプ的グルタミン酸受容体によるGタンパク質活性化

Alpay B Seven1, Ximena Barros-Álvarez1, Marine de Lapeyrière2

  • 1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|July 1, 2021
PubMed
まとめ

C族のGタンパク質結合受容体 (GPCRs) はジマーとして機能する. この研究は,メタボトロピクグルタミン酸受容体2 (mGlu2) の活性化が,新しいメカニズムを通じてGタンパク質結合を可能にするために,トランスメブランドメインを再配置することを明らかにしています.

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