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関連する概念動画

Antibody Structure01:10

Antibody Structure

65.7K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
65.7K
Conformity01:20

Conformity

48.2K
Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group.
48.2K
Antibody Structure and Classes01:25

Antibody Structure and Classes

9.3K
Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.
9.3K
Conformations of Butane02:20

Conformations of Butane

18.2K
Unlike ethane and propane that have only two major conformations, butane has more than two conformers. The staggered form of butane in which the bulky methyl groups on the two carbons are placed on opposite sides, that is, at a dihedral angle of 180°, is the lowest energy, most stable form — called the anti conformer. This conformation is stabilized due to the absence of steric repulsion between the largely spaced out methyl groups. The other two staggered conformations are...
18.2K
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

425
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
425
Conformations of Cycloalkanes02:29

Conformations of Cycloalkanes

14.6K
Adolf von Baeyer attempted to explain the instabilities of small and large cycloalkane rings using the concept of angle strain — the strain caused by the deviation of bond angles from the ideal 109.5° tetrahedral value for sp3  hybridized carbons. However, while cyclopropane and cyclobutane are strained, as expected from their highly compressed bond angles, cyclopentane is more strained than predicted, and cyclohexane is virtually strain-free. Hence, Baeyer’s theory that...
14.6K

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関連する実験動画

Updated: Feb 9, 2026

Author Spotlight: Exploring Behavioral Pathways Through Cross-Species Insights in Foraging and Communication
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Author Spotlight: Exploring Behavioral Pathways Through Cross-Species Insights in Foraging and Communication

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抗体の超変性ループの構造は,コンフォメーション検索アルゴリズムによって再現される.

R E Bruccoleri1, E Haber, J Novotný

  • 1Cellular and Molecular Research Laboratory, Massachusetts General Hospital, Boston 02114.

Nature
|October 6, 1988
PubMed
まとめ

研究者らは,抗体ハイパー変性ループを計算手法でモデル化することに成功しました. この技術は,抗原結合部位を正確に再構築し,抗体工学とタンパク質構造の予測を進める.

科学分野:

  • 構造生物学 構造生物学とは
  • 免疫学 免疫学とは
  • コンピューティング・ケミストリー

背景:

  • 抗体特異性は,抗原結合部位内の超変性ループによって決定される.
  • これらの不規則なループの正確なモデリングは,タンパク質構造の予測に困難です.
  • ループ構造を理解することは,抗体工学と薬剤設計において極めて重要です.

研究 の 目的:

  • 抗体分子の削除された超変性ループを計算的に再構築する.
  • 既知の抗体結晶構造を用いたモデリングプロトコルを検証する.
  • 配列から完全な抗原結合部位を予測する可能性を評価する.

主な方法:

  • ネズミの免疫グロブリンX線構造から超変性のループを削除する.
  • コンフォメーション検索プログラム CONGEN.を使用したループの再構築.
  • ループの形状の生成と,サイトモデルの組み合わせの構築.

主要な成果:

  • McPC 603抗体における超変性ループ再構築のための成功したプロトコルを開発しました.
  • HyHEL-5抗体の超変性ループをモデル化し,結晶構造と良好な一致を達成しました.
  • 抗体結合部位の計算モデリングの精度を実証しました.

さらに関連する動画

CRISPR-Mediated Reorganization of Chromatin Loop Structure
09:20

CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

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Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
10:50

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Published on: September 15, 2010

9.9K

関連する実験動画

Last Updated: Feb 9, 2026

Author Spotlight: Exploring Behavioral Pathways Through Cross-Species Insights in Foraging and Communication
03:53

Author Spotlight: Exploring Behavioral Pathways Through Cross-Species Insights in Foraging and Communication

Published on: November 17, 2023

1.6K
CRISPR-Mediated Reorganization of Chromatin Loop Structure
09:20

CRISPR-Mediated Reorganization of Chromatin Loop Structure

Published on: September 14, 2018

13.1K
Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
10:50

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Published on: September 15, 2010

9.9K

結論:

  • コンピューティング・モデリングは,抗体の高変性ループを正確に再構築することができます.
  • 開発されたプロトコルは,完全な抗原結合部位を予測する有望なことを示しています.
  • この研究は,抗体設計とタンパク質構造の予測に関する将来の研究を促進します.