統合失調症における推論された関係の神経再生障害
Matthew M Nour1, Yunzhe Liu2, Atheeshaan Arumuham3
1Max Planck University College London Centre for Computational Psychiatry and Ageing Research, London WC1B 5EH, UK; Wellcome Centre for Human Neuroimaging (WCHN), University College London, London WC1N 3AR, UK; Department of Psychosis Studies, Institute of Psychiatry Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Cell
|July 1, 2021
まとめ
統合失調症の患者は 休息中に神経再生が妨げられ メンタルマップの形成に 影響を及ぼします 学習と記憶に不可欠な この脳の活動は 健康な個体とは大きく異なります
科学分野:
- 神経科学
- 認知科学
- 精神科
背景:
- 直接的な経験を超えた想像を可能にするには 世界モデルのような 構造化された精神的表現が不可欠です
- ネズミでは,休息中の連続した場所細胞再活性化 (再生) がこれらの表現を支持する.
- 統合失調症は,動物モデルで異常な海馬の再生とリップルの活動を示す,構造化された精神的表現の障害を含むと仮定されています.
研究 の 目的:
- 統合失調症患者の物体関係の推論を必要とするタスク中に 神経再生と海馬のリップル活動を調査する.
- 統合失調症患者と健康な対照群の 神経動態を比較する
主な方法:
- 統合失調症患者および対照群の脳活動を記録するために,磁気脳図 (MEG) が使用されました.
- 視覚体験を再構成することで 観察されていないオブジェクトの関係を推論しました
- 作業後の休憩期間の神経活動が,自発的な神経再活性化 (再生) と海馬の波動力について分析された.
主要な成果:
- 健康な対照群は,提示されたオブジェクトの急速な自発的な神経再活性化 (再生) を示し,推測された関係を反映し,海馬の波動力の増加と一致しました.
- 統合失調症の患者は ニューラル再生が減少し,ヒポカンパスの波動力が増加した.
- これらの神経異常は 行動獲得とタスク構造の表現の障害と相関しています
結論:
- 統合失調症患者での発見は動物モデルと一致し,異常な海馬の再生とリップルの活性を示しています.
- 神経の再生が妨げられ 波動力が変化すると 統合失調症では 構造的な精神的表象や学習の欠陥が生まれます
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