関連する実験動画

Updated: Oct 30, 2025

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
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Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

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単一の Th17 細胞の代謝モデル化により,自己免疫の調節物質が明らかになった

Allon Wagner1, Chao Wang2, Johannes Fessler3

  • 1Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA 94720, USA; Center for Computational Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Cell
|July 3, 2021
PubMed
まとめ

新しいアルゴリズムであるCompassは,単細胞の代謝を分析し,Tヘルパー17 (Th17) 細胞がどのように病原性になるかを明らかにします. ポリアミンの代謝を重要な要因として特定し,自己免疫疾患の新たな治療標的を提供している.

キーワード:
DFMOTヘルパー 17 セル実験的な自己免疫性脳内炎免疫代謝シリコ代謝モデリング多発性硬化症ポリアミンパットレスチン単細胞トランスクリプトミクススペミジン

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