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関連する概念動画

Directing Proteins to the Rough Endoplasmic Reticulum01:34

Directing Proteins to the Rough Endoplasmic Reticulum

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The organelle-specific signaling sequences direct proteins synthesized in the cytosol to their final destination like ER, mitochondria, peroxisomes, etc. Some of the proteins directed to ER are then trafficked via vesicles to other organelles within the cell or the extracellular environment through the Golgi complex. For example, the rough ER synthesizes soluble proteins for transportation to the lysosomes or secretion out of the cell. It can also synthesize transmembrane proteins that can...
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The Unfolded Protein Response01:37

The Unfolded Protein Response

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The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
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Role of ER in the Secretory Pathway01:17

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Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
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Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

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Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
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Protein Translocation Machinery on the ER Membrane01:28

Protein Translocation Machinery on the ER Membrane

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The translocon complex situated on the ER membrane is the main gateway for the protein secretory pathway. It facilitates the transport of nascent peptides into the ER lumen and their insertion into the ER membrane.
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the...
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CRISPR and crRNAs02:53

CRISPR and crRNAs

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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
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Updated: Oct 29, 2025

Online Size-exclusion and Ion-exchange Chromatography on a SAXS Beamline
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ESCRTがバックを取った!

Raunaq A Deo1, William A Prinz1

  • 1National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA.

Cell
|July 9, 2021
PubMed
まとめ
この要約は機械生成です。

ESCRT-III タンパク質機構は 膜の改造で知られており 現在 細菌やシアノバクテリアに存在しています この発見は,ESCRT-IIIのスーパーファミリーは,これまで考えられていたよりも古く,広く存在していることを示しています.

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Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb
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Analysis of SEC-SAXS data via EFA deconvolution and Scatter
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関連する実験動画

Last Updated: Oct 29, 2025

Online Size-exclusion and Ion-exchange Chromatography on a SAXS Beamline
11:09

Online Size-exclusion and Ion-exchange Chromatography on a SAXS Beamline

Published on: January 5, 2017

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Diffuse Reflectance Spectroscopy: Getting the Capillary Refill Test Under One's Thumb
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Analysis of SEC-SAXS data via EFA deconvolution and Scatter
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科学分野:

  • 細胞生物学
  • 分子生物学
  • 微生物学

背景:

  • ESCRT-IIIタンパク質は,真核生物といくつかの古生物の膜変形,芽生え,切断に不可欠である.
  • これらのタンパク質は 機能を遂行するために 線状に組み合わされます

研究 の 目的:

  • バクテリアとシアノバクテリアにおける ESCRT-III ホモログの存在と機能を調査する.
  • ESCRT-IIIスーパーファミリーがユカリオットと古生物を超えて広がっているかどうかを判断する.

主な方法:

  • バクテリアとサイアノバクテリアのゲノムにおける潜在的なESCRT-III同類体を特定するための比較ゲノミクスと配列分析.
  • PspAとVipp1のような特定されたタンパク質の機能を特徴付けるための生化学的および細胞ベースの測定法.

主要な成果:

  • バクテリアのPspAとサイアノバクテリアのVipp1は,ESCRT- IIIタンパク質の機能的同位体として識別された.
  • これらの発見は,ESCRT-III機構がバクテリア,サイアノバクテリア,古生物,および真核生物で保存されていることを示しています.

結論:

  • ESCRT-IIIスーパーファミリーは,これまで認識されていたより広範な進化の歴史を持つ,根本的で古代の細胞系である.
  • バクテリアとサイアノバクテリアのESCRT-III成分の存在は,プロカリオット生命にとって重要な膜ダイナミクスにおける古代の役割を示唆しています.