アルファフォールドによる高精度なタンパク質構造予測

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Updated: Oct 28, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

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John Jumper1, Richard Evans2, Alexander Pritzel2

  • 1DeepMind, London, UK. jumper@deepmind.com.

Nature
|July 15, 2021
PubMed
まとめ

新しい計算法であるAlphaFoldは アミノ酸の配列から タンパク質の構造を正確に予測できます この突破は,構造バイオインフォマティクスとタンパク質研究における大きなボトルネックに対応しています.

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Protein Folding01:22

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Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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