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Updated: Oct 27, 2025

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
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Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

Published on: October 17, 2025

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EGFRの活性化は,レンバチニブに対する肝がんの反応を制限する

Haojie Jin1,2, Yaoping Shi3, Yuanyuan Lv1

  • 1State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Nature
|July 22, 2021
PubMed
まとめ

リンバチニブと表皮成長因子受容体 (EGFR) 阻害剤の組み合わせは,進行肝細胞癌 (HCC) の治療に有望である. この組み合わせ治療は,EGFR濃度が高い進行した肝がん患者のための新しい戦略を提供します.

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Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib09:38

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