腸内サイトカインは,細胞の代謝再プログラムによって嗅覚を調節する
Xiaoyu Tracy Cai1,2,3, Hongjie Li4,5,6, Martin Borch Jensen2,7
1Immunology Discovery, Genentech, Inc., South San Francisco, CA, USA.
Nature
|July 22, 2021
まとめ
フルーツフライの腸内感染症は 脳の細胞を再プログラムし 嗅覚を変化させ 生存を促進します この効果は 炎症と関連しており 年老いたハエでは 常時的に発生し 嗅覚が損なわれます
科学分野:
- 神経科学
- 免疫学
- 遺伝学
背景:
- 感染による嫌悪感は宿主の生存に不可欠です
- 以前の研究では 感覚知覚と 微生物に対する回避行動が 関連していました
- 腸内感染症が感覚知覚に与える直接的な影響は不明である.
研究 の 目的:
- 腸内感染症が 感覚の認識を どう変えたか調べるため
- 感染による嫌悪感の仕組みを理解する
- これらの変化を媒介する 膠質細胞の役割を探る
主な方法:
- ドロソフィラ・メラノガスターをモデル生物として
- 遺伝子発現とシグナル伝達経路の分析 (JAK-STAT)
- 嗅覚による差別と 行動による回避の評価
主要な成果:
- エントロパトゲン感染は 状の細胞を 再プログラムします
- 感染はJAK-STAT信号を活性化し 膠質代謝とニューロン-膠質結合を変化させます
- 汚染された食べ物を避け 蚊の生存率を高めます
- 年齢に伴う腸炎は老いたハエの 膠質細胞を再プログラムし 嗅覚の衰えを引き起こします
結論:
- 腸に由来するサイトカインは 適応性のある膠質代謝の再プログラミングを誘導し 感覚的知覚を変化させます
- このメカニズムは 嗅覚系,特に老いたハエの 持続的な変化を説明します
- 病気の行動や年齢による感覚的衰退の 重要な要因です
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