中脳運動領域における身体活動の機能的多様性
Manuel J Ferreira-Pinto1, Harsh Kanodia1, Antonio Falasconi1
1Biozentrum, Department of Cell Biology, University of Basel, 4056 Basel, Switzerland; Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland.
Cell
|July 24, 2021
まとめ
中脳運動領域 (MLR) には,身体の動きを制御する異なるニューロン群が含まれています. これらのサブポピュレーションは プロジェクションターゲットを用いて 動作を制御し 脳の機能に新たな洞察を与えます
科学分野:
- 神経科学
- モーター コントロール
背景:
- 中脳運動領域 (MLR) は移動に不可欠です.
- 特にパーキンソン病 (PD) の正確な機能については,議論が続いている.
- MLR神経の多様性を理解することは PD治療の進歩の鍵です
研究 の 目的:
- MLR内の異なるニューロン集団を識別し,機能的に特徴づけること.
- 運動制御におけるこれらのサブ集団の特定の役割を解明する.
- ロコモーション以外のMLR機能を区別する.
主な方法:
- ニューロン集団を区別するために軸索投影トレーシングを使用した.
- マウスの遺伝子を使って 細胞タイプを特定した.
- モータータスク中のニューロンの活動プロファイルを記録します.
- オプトジェネティックな 機能喪失と機能増強の実験を
主要な成果:
- 予測目標に基づいて2つの混合したグルタマタージックMLRサブ集団を特定した.
- 脊髄に発射するニューロンは 主に育成と体の拡張を コントロールします
- Rbp4陽性ニューロンが上昇して基底ギャングリアを標的とし,前肢の行動 (ハンドリング,グルーミング) を調節する.
結論:
- MLRは機能的に特化したグルタマタージックニューロンのサブ集団を宿している.
- これらのサブポピュレーションは,その投影標的 (脊髄と基礎帯) によって層分かれています.
- MLRニューロンはこれまで考えられていたよりも 複雑な行動や運動の調節を含む 幅広い行動を制御します
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