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Updated: May 5, 2026

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue
06:14

Novel Passive Clearing Methods for the Rapid Production of Optical Transparency in Whole CNS Tissue

Published on: May 8, 2018

9.0K

ELAVL4,スプライシング,およびグルタマタージック機能障害は,MAPT変異の脳オーガノイドにおけるニューロン喪失に先行する

Kathryn R Bowles1, M Catarina Silva2, Kristen Whitney3

  • 1Ronald M. Loeb Center for Alzheimer's Disease, Friedman Brain Institute, Departments of Genetics and Genomic Sciences, Neuroscience, and Neurology, Icahn School of Medicine at Mount Sinai (ISMMS), New York, NY 10029, USA.

Cell
|July 27, 2021
PubMed
まとめ

フロントテンポラル認知症 (FTD) 研究では,幹細胞モデルを用いて,早期のタウの蓄積とニューロン喪失に先立つグルタミン酸経路の変化を明らかにしています. PIKFYVE阻害剤は,変異性ニューロンのグルタミン酸毒性の救済に有望であることが示されました.

キーワード:
ELAVL4 についてMAPTオートファジーフロントテンポラル認知症グルタマタージックニューロンオーガノイドスプライシングシナプス信号タオパシー

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