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Updated: Oct 26, 2025

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
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人間のNMDA受容体に対するケタミン作用の構造的基礎

Youyi Zhang1,2, Fei Ye3, Tongtong Zhang1,2

  • 1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China.

Nature
|July 29, 2021
PubMed
まとめ

抗うつ薬ケタミンの一番重要な成分であるS-ケタミンは,N-メチル-D-アスパルテート (NMDA) 受容体に結合する. 構造分析は特定の結合部位と相互作用を明らかにし,ケタミン基抗うつ薬の開発を導いています.

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