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In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
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BRCA1-BARD1核細胞認識と普遍化のメカニズム

Qi Hu1, Maria Victoria Botuyan1, Debiao Zhao1

  • 1Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.

Nature
|July 29, 2021
PubMed
まとめ

BRCA1-BARD1複合体は,ヒストンの改変によってDNAの二重鎖の断裂に結合し,ユビキチン結合酵素を誘発する. このメカニズムはDNA修復と癌の発生における その役割を説明します

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