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Updated: Oct 26, 2025

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Published on: June 13, 2022

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σ-およびπ-C-C結合の窒素誘導アジデーションによるダイアミン合成

Ming-Ming Wang1, Tin V T Nguyen1, Jerome Waser1

  • 1Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fédérale de Lausanne, EPFL, 1015 Lausanne, Switzerland.

Journal of the American Chemical Society
|August 2, 2021
PubMed
まとめ

多様なダイアミンを合成するのは 難しいことです この研究では,アルケン,サイクロプロパン,サイクロブタンのための新しい窒素誘導ダイアジデーション法が導入され,保護された1,2,1,4ダイアミンへの効率的なアクセスを可能にします.

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Preparation of 1° Amines: Azide Synthesis

Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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