関連する実験動画

Updated: Oct 25, 2025

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System
08:15

Generation of a RIP1 Knockout U937 Cell Line Using the CRISPR-Cas9 System

Published on: April 11, 2025

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ヒトのTBK1欠乏は,TNF誘発の細胞死によって引き起こされる自己炎症を引き起こす

Justin Taft1, Michael Markson1, Diana Legarda2

  • 1Center for Inborn Errors of Immunity, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Cell
|August 7, 2021
PubMed
まとめ

TANK結合キナーゼ1 (TBK1) の機能喪失による変異は,ヒトでは重症感染症ではなく,自己炎症を引き起こす. 抗TNF療法により,TNF誘発細胞死が減少することで,患者の状態が改善されました.

キーワード:
IKKE についてIRF3 についてRIPK1 についてTBK1欠乏症TNFアルファ自発性炎症インターフェロンタイプIウイルスの感受性

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