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Updated: Oct 25, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

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凝縮物におけるタウの適合的膨張は,不可逆的集積を促進する

Jitao Wen1,2, Liu Hong3, Georg Krainer4

  • 1National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China.

Journal of the American Chemical Society
|August 10, 2021
PubMed
まとめ

タンパク質の液体相分離 (LLPS) は細胞の機能と病気を駆動します 異常型タウタンパク質のLLPSは結合領域を暴露し,神経変性疾患の結合を加速するクラスタを形成する.

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