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関連する概念動画

Group Design02:01

Group Design

9.3K
The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
9.3K
Schemas01:42

Schemas

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A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
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Overview of Transposition and Recombination02:13

Overview of Transposition and Recombination

16.4K
Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
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Introduction to Structures01:30

Introduction to Structures

2.5K
A structure is defined as a system of interconnected members designed to support or transfer forces and successfully withstand the loads acting on them. The internal forces of a structure can be determined by decomposing the structure and analyzing the free-body diagrams of the individual members or of a combination of members. This helps in understanding the structural elements' behavior and ensuring that the structure is stable and can withstand the subjected loads.
There are three main...
2.5K
Space Trusses01:25

Space Trusses

2.1K
A space truss is a three-dimensional counterpart of a planar truss. These structures consist of members connected at their ends, often utilizing ball-and-socket joints to create a stable and versatile framework. The space truss is widely used in various construction projects due to its adaptability and capacity to withstand complex loads.
At the core of a space truss lies the fundamental unit known as the tetrahedron. This structure is composed of six members that form a three-dimensional shape...
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Space Trusses: Problem Solving01:29

Space Trusses: Problem Solving

1.6K
A space truss is a three-dimensional counterpart of a planar truss. These structures consist of members connected at their ends, often utilizing ball-and-socket joints to create a stable and versatile framework. Due to its adaptability and capacity to withstand complex loads, the space truss is widely used in various construction projects.
Consider a tripod consisting of a tetrahedral space truss with a ball-and-socket joint at C. Suppose the height and lengths of the horizontal and vertical...
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Laser-Capture Microdissection RNA-Sequencing for Spatial and Temporal Tissue-Specific Gene Expression Analysis in Plants
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空間トランスクリプトミクスを用いた組織構造の探索

Anjali Rao1, Dalia Barkley1, Gustavo S França1

  • 1Institute for Computational Medicine, NYU Langone Health, New York, NY, USA.

Nature
|August 12, 2021
PubMed
まとめ
この要約は機械生成です。

スペーストランスクリプトミックは 組織にわたる遺伝子の活動をマップし 生命科学の研究を進めています この技術は,様々な生物学的および病気の文脈で仮説の生成とテストを可能にします.

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科学分野:

  • 分子生物学
  • ゲノミクス
  • システム生物学

背景:

  • 細胞組織における遺伝子活動の役割を理解することは,生命科学にとって極めて重要です.
  • 次世代のシーケンシングとイメージングを用いた空間トランスクリプトミックは,組織空間全体で遺伝子発現を測定します.
  • この技術は神経科学,発達生物学,植物生物学,がん研究に応用できます

研究 の 目的:

  • 空間トランスクリプトミックの技術を見直す
  • 空間トランスクリプトミクスのデータ分析方法について説明する.
  • 仮説の生成とテストのための空間トランスクリプトミックの有用性を強調する.

主な方法:

  • 空間トランスクリプトーム技術のレビュー
  • 空間トランスクリプトミックのデータ分析操作の記述.
  • 空間トランスクリプトミクスを用いた仮説テストの実験デザインの議論.

主要な成果:

  • 空間トランスクリプトミクスは組織内の遺伝子発現の大規模なアトラスを提供します.
  • データ分析は探索分析と仮説生成を可能にします.
  • 空間トランスクリプトミックのデータは,包括的な洞察を得るために他のデータ形式と統合できます.

結論:

  • 組織組織を理解するための強力なツールです
  • 様々な生物学的および疾患の文脈で仮説の生成とテストを容易にする.
  • 他のデータ形式との統合は,生物学的発見のための拡張可能な枠組みを提供します.