デプシペプチド核酸:新型原核酸候補のプレバイオティック形成,オリゴメリゼーション,自己組み立て
David M Fialho1, Suneesh C Karunakaran1, Katherine W Greeson1
1School of Chemistry and Biochemistry and Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Journal of the American Chemical Society
|August 16, 2021
まとめ
初期の生命の情報ポリマーは かつて考えられていたより 容易に形成されたのかもしれません 新しいデプシペプチド核酸 (DepsiPNA) 候補は,前生物学的形成と自己組み立て能力を示し,RNA-firstの制約を緩和しています.
科学分野:
- 生命の研究の起源
- プリバイオティック化学
- 分子進化
背景:
- 初期の地球での情報ポリマーの形成の正確なメカニズムは不明である.
- RNA世界仮説は,プリバイオティックRNAオリゴーマー形成を前提としているが,これを証明するのは困難である.
- 祖先のポリマーまたはプロトRNAは RNAに先立つ可能性のある代替品であり,潜在的により大きな自己組み立て性能を提供します.
研究 の 目的:
- 新型核酸アナログであるデプシペプチド核酸 (DepsiPNA) をプロトRNAの候補として調査する.
- DepsiPNAのプリバイオティック形成と自己組織化の可能性を評価する.
主な方法:
- 可能性のあるプレバイオティック条件下でデプシペプチド核酸単体合成.
- 水溶液の脱水によるオリゴメリゼーションの誘導
- DepsiPNA オリゴマーの自己組み立てと水解抵抗の評価
主要な成果:
- デプシペプチド核酸モノメアは,妥当なプレバイオティック条件下で形成される.
- これらのモノメアは乾燥時に自発的に核塩基機能化デプシペプチドに変異する.
- DepsiPNA オリゴーマーには,補完的な自己組織化と,組み立てられた状態で水解への耐性がある.
結論:
- デプシペプチド核酸 (DepsiPNA) は,潜在的なプロトRNA分子として魅力的な性質を示しています.
- DepsiPNAの自発的形成と自己組み立ては,初期の地球での初期情報ポリマー形成が容易であったことを示唆しています.
- 厳格なRNA-firstシナリオの緩和は 生命のポリマーの起源に よりアクセシブルな経路を提供するかもしれません
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