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Updated: Oct 23, 2025

Isolation of mRNAs Associated with Yeast Mitochondria to Study Mechanisms of Localized Translation
14:44

Isolation of mRNAs Associated with Yeast Mitochondria to Study Mechanisms of Localized Translation

Published on: March 14, 2014

13.1K

二重の膜状の臓器細胞は,直角的な真核転移の空間的分離を可能にします

Christopher D Reinkemeier1, Edward A Lemke1

  • 1Biocentre, Departments of Biology and Chemistry, Johannes Gutenberg University Mainz, Hanns-Dieter-Hüsch-Weg 17, 55128 Mainz, Germany; Institute of Molecular Biology gGmbH, Ackermannweg 4, 55128 Mainz, Germany; Structural and Computational Biology Unit and Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

Cell
|August 25, 2021
PubMed
まとめ

科学者たちは 細胞膜に微小な膜のような働きをする 合成臓器を作りました これらのフィルムは 細胞が特定のタンパク質を 生み出し 細胞機能を正確に制御し 合成生物学の進歩を可能にします

キーワード:
2Dフェーズ分離酵素工学遺伝子コードの拡張膜シグナリングオートゴーナル翻訳合成生物学合成生物分子凝縮物

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Visualization of Endoplasmic Reticulum Localized mRNAs in Mammalian Cells10:24

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Eukaryotic Compartmentalization

One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...
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Regulated mRNA Transport02:22

Regulated mRNA Transport

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The Endoplasmic Reticulum

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Golgi Apparatus

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The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
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Directing Proteins to the Rough Endoplasmic Reticulum

The organelle-specific signaling sequences direct proteins synthesized in the cytosol to their final destination like ER, mitochondria, peroxisomes, etc. Some of the proteins directed to ER are then trafficked via vesicles to other organelles within the cell or the extracellular environment through the Golgi complex. For example, the rough ER synthesizes soluble proteins for transportation to the lysosomes or secretion out of the cell. It can also synthesize transmembrane proteins that can...
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