下垂体ドーパミンニューロンは,持続的なcAMPシグナル伝達によって交配を誘導する
Stephen X Zhang1, Andrew Lutas1, Shang Yang2
1Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Nature
|August 26, 2021
まとめ
ドーパミンニューロンは 視床下部のマウスで 交配を制御します 彼らの活動により,交配の動機と飽和感は,中部前視領域に信号を蓄積または抑制することによって調節されます.
科学分野:
- 神経科学
- 神経生物学
- 行動神経科学
背景:
- 暫定的な神経調節は 神経回路と動機付け状態に大きな影響を及ぼします
- 交尾衝動の背後にある ドーパミナージックメカニズムと その持続性を理解することは 極めて重要です
研究 の 目的:
- オスのマウスの交尾衝動と飽和感を調節する ドーパミンニューロンの役割を調べる
- 交配に関連したドーパミンの放出に関与する細胞内信号伝達経路とその行動的効果を解明する.
主な方法:
- 下垂体内の特定のドーパミンニューロン (AVPV/PVpo) を刺激し,抑制するために光遺伝学を使用した.
- メディアル・プレオプティック領域 (MPOA) の細胞内信号伝達 (cAMP,PKA) を追跡および操作するための光学および分子技術を使用した.
- 男性マウスの交尾動機と飽和感に関連した行動反応が観察されました.
主要な成果:
- ドーパミンニューロンは,交尾衝動と飽和感を制御する.
- cAMPとPKAの活動によって誘発されるメディアル・プレオプティック領域 (MPOA) のドーパミン放出が交配の利点を高めます.
- 交配が成功すると,MPOA内のドーパミントランジタがなくなり,AVPV/PVpoニューロンの操作により,交配の動機と飽和感が変化します.
結論:
- AVPV/PVpoドーパミンニューロンの信号の蓄積や抑制は 数分から数日の間に交配行動を制御します
- これらのドーパミンニューロンは 交配行動の開始と停止の両方の重要なレギュレータであり 動機付けの制御における二重の役割を示しています
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