将来の光学的流れをシミュレートすることによって,網膜波の主要な視覚的運動検出
Xinxin Ge1, Kathy Zhang1, Alexandra Gribizis1
1Department of Neuroscience, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA.
Science (New York, N.Y.)
|August 26, 2021
まとめ
眼が開く前に ネズミの自発的な網膜波が 光の流れを模倣し 視覚回路の発達を誘導します この波の方向性を妨害すると ニューロンが視覚的動きを処理し 早期の活動が視覚的反応を どう形作るかを明らかにします
科学分野:
- 神経科学
- 発達生物学
- 視覚システム開発
背景:
- 環境への反応能力の出現には 感覚経験は必要ありません
- 哺乳類では,自発的な網膜活動が,眼を開ける前に網膜形成と眼特異的分離を精製する.
- この早期の網膜活動が,高次元の視覚反応の発達における役割は十分に理解されていません.
研究 の 目的:
- 初期の視覚処理における 網膜の自発的な波の役割を調査する.
- 網膜波の空間的伝播が 光学流動パターンに似ているかどうかを判断する.
- これらの波の方向性が方向選択性ニューロンの発達にどのように影響するかを調べる.
主な方法:
- 新生マウスモデルにおける自発的な網膜波の伝播パターンの分析.
- 波の方向性を破壊する 遺伝的または薬学的操作
- 応答特性を評価するために,上部コリキュルニューロンの電気生理学的記録.
主要な成果:
- 網膜波が光学的な流れのように空間的に広がる特定の発達窓が特定されました.
- 大人の方向選択性網膜回路に必要な回路構成要素は,波の方向性にも必要です.
- 網膜波の方向性の慢性的な障害は,上部コリキュルスのニューロンの方向選択反応の変化をもたらした.
結論:
- 視覚系の開発は 光の流れのような 現実の刺激をシミュレートする自発的な活動パターンを利用します
- この自己生成活動は 視覚回路の自己組織化,特に運動処理を指示します
- 早期の網膜波の方向性は,成熟した視覚応答の特性を確立するために不可欠です.
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