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Updated: Oct 22, 2025

An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering
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An All-in-one Sample Holder for Macromolecular X-ray Crystallography with Minimal Background Scattering

Published on: July 6, 2019

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時間解析マクロ分子結晶学の進歩と課題

Gisela Brändén1, Richard Neutze2

  • 1Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.

Science (New York, N.Y.)
|August 27, 2021
PubMed
まとめ

ダイナミックなタンパク質構造の変化を明らかにします. 先進的なシリアル結晶学技術は,生物学的マクロモレキュルの超高速で遅い構造変化を捉え,詳細な化学的洞察を提供します.

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X-ray Crystallography02:18

X-ray Crystallography

The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
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X-ray Diffraction of Biological Samples

X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
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