関連する実験動画

Updated: Oct 22, 2025

Small RNA Transfection in Primary Human Th17 Cells by Next Generation Electroporation
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Small RNA Transfection in Primary Human Th17 Cells by Next Generation Electroporation

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免疫刺激 RNA RN7SL1は,CAR-T細胞が自律的および内生的な免疫機能を強化することを可能にします

Lexus R Johnson1, Daniel Y Lee2, Jacqueline S Eacret2

  • 1Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Mark Foundation Center for Immunotherapy, Immune Signaling, and Radiation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Cell
|August 31, 2021
PubMed
まとめ

エンジニアリングされたCAR-T細胞はRN7SL1RNAを放出し,抗腫瘍免疫を強化し,抗原の損失を克服します. この戦略はT細胞の機能と内生的な免疫反応を高め,固体腫瘍の拒絶を改善します.

キーワード:
CAR-T細胞,RN7SL1,7SL,パターン認識受容体,RIG-I,MDA5,インターフェロン,エクソソーム,細胞外膀

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