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Updated: Oct 21, 2025

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AIM2は,パノプトーシスと宿主防御を駆動するために,ピリンとZBP1と複合体を形成する

SangJoon Lee1, Rajendra Karki1, Yaqiu Wang1

  • 1Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.

Nature
|September 2, 2021
PubMed
まとめ

AIM2はピリンとZBP1を調節し,炎症性細胞死の一種であるPANoptosisを駆動し,感染からホストを保護します. この発見は,新しいAIM2媒介複合体,AIM2 PANoptosomeを定義し,先天的な免疫の理解を進めている.

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