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Updated: Oct 21, 2025

Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
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Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

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適合エントロピーの定量化により,結合された折り畳みと結合における無秩序な側面領域の効果が解明される

Frederik Friis Theisen, Lasse Staby, Frederik Grønbæk Tidemand1

  • 1Structural Biophysics, X-ray and Neutron Science, The Niels Bohr Institute, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen Ø, Denmark.

Journal of the American Chemical Society
|September 2, 2021
PubMed
まとめ

この研究は,本質的に無秩序なタンパク質 (IDP) の構成エントロピーの変化を定量化するために熱力学的アプローチを採用しています. 強化された方法は,IDPの結合相互作用を正確に分析し,従来の技術でしばしば見逃された重要な構造的およびメカニズム的洞察を明らかにします.

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