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Updated: Oct 21, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

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チオエーテル誘導 NiH 誘導リモート γ-C ((sp3) -H アルケンの 1,4,2-ダイオクサゾール-5-オンによる水酸化

Bingnan Du1, Yuxin Ouyang1, Qishu Chen1

  • 1State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

Journal of the American Chemical Society
|September 8, 2021
PubMed
まとめ

この研究は,アルケンの遠隔C−H結合アミデーションのためのニッケル水素触媒法を導入する. このプロセスは,ガンマメチレン部位に機能化を指示することによって,高収量と地域選択性を達成します.

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In the first step of the mechanism, the acid protonates the carbonyl oxygen resulting in a resonance-stabilized cation, which subsequently loses an α-hydrogen to form an enol tautomer. The C=C bond in an enol is highly nucleophilic because of the electron-donating nature of the –OH group. Consequently, the double bond attacks an electrophilic halogen to form a...
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